Orthotics, including foot inserts and knee braces, can treat various knee conditions by addressing alignment, providing support, and reducing stress, especially for Patellofemoral Pain Syndrome (Runner's Knee), IT Band Syndrome, and Osteoarthritis, while also aiding recovery from ligament injuries (ACL, MCL, PCL) and meniscus damage, often by stabilizing the foot's biomechanics to improve overall lower limb function.